#define CTO OpenAI

It’s been two years since I wrote #define CTO, in which I documented my quest for a role where I could have scalable impact by writing code. I’ve finally found that role, though not by seeking it — instead, I sought out a problem more important to me than my role within it, brought together the right people, and found that I can best make them effective by writing code.

Source: #define CTO OpenAI

Git Strategizing: Branch, Commit, Review, and Merge – Simple Talk

Being a pragmatist, I recognize that—like the eternal spaces vs tabs debate—one’s branching and merging styles are often held dear. If I may ask you to set all that aside for just a few minutes though, have a look and see if any of the following might make your environment more productive. The next caveat is that this article is focused on Git, which is a distributed version control system (DVCS). The conclusions may or may not be relevant to other DVCS’s but probably not to centralized version control systems, like Subversion, where branches can be expensive.

Git Strategizing: Branch, Commit, Review, and Merge

Source: Git Strategizing: Branch, Commit, Review, and Merge – Simple Talk

Ask HN: Teaching programming in computational biology? | Hacker News

Hi everyone,I work at a university institute of computational biology. Besides doing research, we also teach quite a few courses for biology students, many of which include an introduction to programming (mostly with R, but also Python). We have a long-standing debate as to what the best approach to this is, and I would like to hear some of your opinions on the matter.

Basically, we have two factions: the “tools-first” and the “fundamentals-first” approach. The supporters of “tools-first” argue that we are teaching biologists, not software developers. They like to teach the specific tools (languages, libraries, functions, etc.) that our students are actually going to need as quickly as possible. To cover as much ground as possible, they are willing to sacrifice a deeper understanding of programming.

Ask HN: Teaching programming in computational biology?

Source: Ask HN: Teaching programming in computational biology? | Hacker News

Mathematician-M.D. solves one of the greatest open problems in the history of mathematics – USC Viterbi | School of Engineering

Athanassios Fokas, a mathematician from the Department of Applied Mathematics and Theoretical Physics of the University of Cambridge and visiting professor in the Ming Hsieh Department of Electrical Engineering at the USC Viterbi School of Engineering has announced the solution of one of the long-standing problems in the history of mathematics, the Lindelöf Hypothesis.

The solution, first published in arXiv, has far reaching implications for fields like quantum computing, number theory, and encryption which forms the basis for cybersecurity.

Source: Mathematician-M.D. solves one of the greatest open problems in the history of mathematics – USC Viterbi | School of Engineering

GCCBOSC18 – 26/06/2018 Daily Notes

CWL Tutorial



GATK Training


In order to make our time together as effective as possible, you’ll need to do a bit of homework before coming to the workshop session: download a data bundle and get GATK4 installed on your laptop. To be clear, you will not have time to do this at the start of the session so it’s imperative that you do this ahead of time.

1) Download the “gatk_bundle.zip” data bundle containing data that we will use in the hands-on exercises:
Direct link: https://drive.google.com/open?id=1ixEFNgWQBf79eRVqhKv9OGpXzGzcrbn2
Enclosing folder (containing additional material for further reading): https://drive.google.com/drive/folders/1U6Zm_tYn_3yeEgrD1bdxye4SXf5OseIt?usp=sharing

2) Install Docker on your laptop and download the GATK4 container image, which contains all the system dependencies needed to run GATK4. Please follow the instructions provided here:

If for whatever reason you are unable to follow the docker installation instructions, the recommended alternative is to use the Conda environment that we provide to manage dependencies, as described in the github repository README:

And if that doesn’t work for you, for the purposes of this workshop you can just get the GATK package, as long as you make sure you have Java 8 installed on your laptop: https://github.com/broadinstitute/gatk/releases/download/

Thank you and see you in Portland!

GATK Haplotype Called

CNN, gCNV Germline CNV Calling
Probabilistic Graphical Models


The materials are now ready for download. The gatk_bundle.zip package contains the data that is sed in the hands-on exercises. The “worksheets” directory contains the exercise instructions. The “dayX” directories contain all the presentation slide decks from the workshop.


PDFs and gatk_bundle: http://broad.io/gatk-1803
Installation prep: https://broad.io/gatk-w-prep

PairHMM depends on the machine you are running on.

15k genomes in 2 weeks.
76k genomes WGS processing
GenomicsDB gives 100k genomes, but still need some work for doing more than that.


docker run -v /path/gatk_data


Somatic Variant Analysis
Call Variants per Sample
Haplotype Caller in GVCF mode

Alibaba Cloud
Google Cloud Platform
IBM Cloud

Not only of for the cloud
BIGStack* 2.0

docker run -v /home/raony/gccbosc/gatk/gatk_bundle/2-germline/:/gatk/gatk_data -it broadinstitute/gatk:

gatk HaplotypeCaller -R /gatk/gatk_data/ref/ref.fasta -I /gatk/gatk_data/bams/mother.bam -O /gatk/gatk_data/sandbox/variants.vcf
Using GATK jar /gatk/build/libs/gatk-package-

gatk ValidateSamFile -I bams/mother.bam -MODE SUMMARY

gatk –java-options “-Xmx4G” MarkDuplicatesSpark -R ref/ref.fasta -I bams/mother.bam -O sandbox/mother_dedup.bam -M sandbox/metrics.txt — –spark-master local[*]
Using GATK jar /gatk/build/libs/gatk-package-

gatk –java-options “-Xmx4G” HaplotypeCaller -R /gatk/gatk_da/ref/ref.fasta -I /gatk/gatk_data/bams/mother.bam -O /gatk/gatk_data/sandbox/mother.g.vcf -ERC GVCF

gatk –java-options “-Xmx4G” HaplotypeCaller -R /gatk/gatk_da/ref/ref.fasta -I /gatk/gatk_data/bams/father.bam -O /gatk/gatk_data/sandbox/father.g.vcf -ERC GVCF

10reads of difference beetwen markduplicates, markduplicatesspark, they are trying to explain that.

7 different levels of certification
Stringent Options Available

export GATK_GCS_STAGING=gs://gatk-jar-cache/
gatk MarkDuplicatesSpark -R gs://gatk-workshops/GCCBOSC2018/ref/ref.fasta -I gs://gatk-workshops/GCCBOSC2018/ref/ref.fasta -O mother_dedup.bam -M metrics.txt — –spark-runner GCS –cluster aardvark-01