Scientists unveil the ‘most clever CRISPR gadget’ so far – STAT

A new CRISPR system can switch single letters of the genome efficiently, in a way that scientists say could reliably repair many disease-causing mutations.

For all the hoopla about CRISPR, the revolutionary genome-editing technology has a dirty little secret: it’s a very messy business. Scientists basically whack the famed double helix with a molecular machete, often triggering the cell’s DNA repair machinery to make all sorts of unwanted changes to the genome beyond what they intended.

On Wednesday, researchers unveiled in Nature a significant improvement — a new CRISPR system that can switch single letters of the genome cleanly and efficiently, in a way that they say could reliably repair many disease-causing mutations.

Source: Scientists unveil the ‘most clever CRISPR gadget’ so far – STAT